Ontology highlight
ABSTRACT:
SUBMITTER: Kim D
PROVIDER: S-EPMC6648602 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Kim Dahye D Alam Mohammad Shariful MS Chung Wook-Jin WJ Koo Sangho S
ACS omega 20190607 6
A new olefination protocol utilizing ethyl bromoacetate was highlighted, in which magnesium enolate of the ester coupled with C<sub>20</sub> dialdehyde <b>6</b>, and double eliminations of the protected hydroxyl groups and bromine atoms of the coupling bromohydrin product, efficiently produced norbixin <b>1</b> after concomitant hydrolysis of the ester. A new (C<sub>7</sub> + C<sub>10</sub> + C<sub>7</sub>) disconnection approach was demonstrated for the synthesis of norbixin ethyl ester <b>2</b ...[more]