Ontology highlight
ABSTRACT:
SUBMITTER: Guo JU
PROVIDER: S-EPMC4284063 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Guo Junjie U JU Szulwach Keith E KE Su Yijing Y Li Yujing Y Yao Bing B Xu Zihui Z Shin Joo Heon JH Xie Bing B Gao Yuan Y Ming Guo-Li GL Jin Peng P Song Hongjun H
Frontiers in biology 20140201 1
Mounting evidence points to critical roles for DNA modifications, including 5-methylcytosine (5mC) and its oxidized forms, in the development, plasticity and disorders of the mammalian nervous system. The novel DNA base 5-hydroxymethylcytosine (5hmC) is known to be capable of initiating passive or active DNA demethylation, but whether and how extensively 5hmC functions in shaping the post-mitotic neuronal DNA methylome is unclear. Here we report the genome-wide distribution of 5hmC in dentate gr ...[more]