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Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention.

ABSTRACT: DNA methylation is a dynamic epigenetic mark regulating gene function and are implicated in the pathophysiology of schizophrenia and autism. Environmental exposures such as inflammation and diet modify the epigenome and may explain why prenatal exposure to inflammation increase risk of neurodevelopmental disorders. This manuscript presents genome-wide DNA methylation data (GSE102942) generated from adult offspring brain prenatally exposed to Maternal Immune Activation (MIA). Methylome of the adult brain supplemented with omega-3 polyunsaturated fatty acids (PUFA) is also described. DNA methylation across gene regulatory regions were measured using MSP-I digestion and Reduced Representation Bisulfite Sequencing (RRBS) method.

SUBMITTER: Basil P

PROVIDER: S-EPMC6811979 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention.

Basil Paul P Li Qi Q McAlonan Grainne M GM Sham Pak-Chung PC

Data in brief 20190926

DNA methylation is a dynamic epigenetic mark regulating gene function and are implicated in the pathophysiology of schizophrenia and autism. Environmental exposures such as inflammation and diet modify the epigenome and may explain why prenatal exposure to inflammation increase risk of neurodevelopmental disorders. This manuscript presents genome-wide DNA methylation data (GSE102942) generated from adult offspring brain prenatally exposed to Maternal Immune Activation (MIA). Methylome of the adu ...[more]

PMID: 31667312

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