Ontology highlight
ABSTRACT:
SUBMITTER: Young JC
PROVIDER: S-EPMC4284639 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Nature communications 20141219
The hallmark of enteropathogenic Escherichia coli (EPEC) infection is the formation of actin-rich pedestal-like structures, which are generated following phosphorylation of the bacterial effector Tir by cellular Src and Abl family tyrosine kinases. This leads to recruitment of the Nck-WIP-N-WASP complex that triggers Arp2/3-dependent actin polymerization in the host cell. The same phosphorylation-mediated signalling network is also assembled downstream of the Vaccinia virus protein A36 and the p ...[more]