Ontology highlight
ABSTRACT:
SUBMITTER: Liszczak G
PROVIDER: S-EPMC6505472 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Liszczak Glen G Diehl Katharine L KL Dann Geoffrey P GP Muir Tom W TW
Nature chemical biology 20180716 9
Recent studies report serine ADP-ribosylation on nucleosomes during the DNA damage response. We unveil histone H3 serine 10 as the primary acceptor residue for chromatin ADP-ribosylation and find that specific histone acetylation marks block this activity. Our results provide a molecular explanation for the well-documented phenomenon of rapid deacetylation at DNA damage sites and support the combinatorial application of PARP and HDAC inhibitors for the treatment of PARP-dependent cancers. ...[more]