Selective pressures on the olfactory receptor repertoire since the human-chimpanzee divergence.
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ABSTRACT:
SUBMITTER: Gimelbrant AA
PROVIDER: S-EPMC428465 | biostudies-literature | 2004 Jun
REPOSITORIES: biostudies-literature
Publications
Selective pressures on the olfactory receptor repertoire since the human-chimpanzee divergence.
Gimelbrant Alexander A AA Skaletsky Helen H Chess Andrew A
Proceedings of the National Academy of Sciences of the United States of America 20040603 24
The availability of the sequence of the chimpanzee genome provides an opportunity to examine human genes and their chimpanzee orthologs and to analyze selective pressures that have been shaping the olfactory receptor repertoire since the human-chimpanzee divergence. We determined the ratio of nonsynonymous to synonymous changes for each of 186 orthologous pairs and then examined how the distribution of these ratios compares with the distribution expected under neutral drift. Consistent with the ...[more]
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