Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery.
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ABSTRACT:
SUBMITTER: Gaitor JC
PROVIDER: S-EPMC5571731 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
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Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery.
Gaitor Jamie C JC Paul Lauren M LM Reardon Melissa M MM Hmissa Taha T Minkowicz Samuel S Regner Matthew M Sheng Yinghong Y Michael Scott F SF Isern Sharon S Mirjafari Arsalan A
Chemical communications (Cambridge, England) 20170701 59
This study introduces a novel class of imidazolium- and ammonium-based ionic liquids possessing two C<sub>12</sub> and C<sub>14</sub> tails and thioether linkers designed for lipoplex-mediated DNA delivery. Imidazolium-based ionic liquids displayed efficient gene delivery properties with low toxicity. Thiol-yne click chemistry was employed for the facile and robust synthesis of these thioether-based cationic lipioids with enhanced lipophilicity and low fluidity. ...[more]
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