Ontology highlight
ABSTRACT:
SUBMITTER: Pores Fernando AT
PROVIDER: S-EPMC4286542 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Pores Fernando A T AT Andrabi S S Cizmecioglu O O Zhu C C Livingston D M DM Higgins J M G JM Schaffhausen B S BS Roberts T M TM
Oncogene 20140707 19
Polyoma small T antigen (PyST), an early gene product of the polyoma virus, has been shown to cause cell death in a number of mammalian cells in a protein phosphatase 2A (PP2A)-dependent manner. In the current study, using a cell line featuring regulated expression of PyST, we found that PyST arrests cells in mitosis. Live-cell and immunofluorescence studies showed that the majority of the PyST expressing cells were arrested in prometaphase with almost no cells progressing beyond metaphase. Thes ...[more]