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Genetic ancestry influences asthma susceptibility and lung function among Latinos.

ABSTRACT: Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest.To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children.We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20% increase in each ancestry.Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95% CI: 0.66-0.78, P = 8.0 × 10(-15)), while African ancestry was associated with higher odds of asthma (OR = 1.40, 95% CI: 1.14-1.72, P = .001). These associations were robust to adjustment for covariates related to early life exposures, air pollution, and socioeconomic status. Among children with asthma, African ancestry was associated with lower lung function, including both pre- and post-bronchodilator measures of FEV1 (-77 ± 19 mL; P = 5.8 × 10(-5) and -83 ± 19 mL; P = 1.1 x 10(-5), respectively) and forced vital capacity (-100 ± 21 mL; P = 2.7 × 10(-6) and -107 ± 22 mL; P = 1.0 x 10(-6), respectively).Differences in the proportions of genetic ancestry can partially explain disparities in asthma susceptibility and lung function among Latinos.

SUBMITTER: Pino-Yanes M

PROVIDER: S-EPMC4289103 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Genetic ancestry influences asthma susceptibility and lung function among Latinos.

Pino-Yanes Maria M Thakur Neeta N Gignoux Christopher R CR Galanter Joshua M JM Roth Lindsey A LA Eng Celeste C Nishimura Katherine K KK Oh Sam S SS Vora Hita H Huntsman Scott S Nguyen Elizabeth A EA Hu Donglei D Drake Katherine A KA Conti David V DV Moreno-Estrada Andres A Sandoval Karla K Winkler Cheryl A CA Borrell Luisa N LN Lurmann Fred F Islam Talat S TS Davis Adam A Farber Harold J HJ Meade Kelley K Avila Pedro C PC Serebrisky Denise D Bibbins-Domingo Kirsten K Lenoir Michael A MA Ford Jean G JG Brigino-Buenaventura Emerita E Rodriguez-Cintron William W Thyne Shannon M SM Sen Saunak S Rodriguez-Santana Jose R JR Bustamante Carlos D CD Williams L Keoki LK Gilliland Frank D FD Gauderman W James WJ Kumar Rajesh R Torgerson Dara G DG Burchard Esteban G EG

The Journal of allergy and clinical immunology 20141006 1

<h4>Background</h4>Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest.<h4>Objective</h4>To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children.<h4>Methods</h4>We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated t ...[more]

PMID: 25301036

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Project description:BackgroundSelf-identified race or ethnic group is used to determine normal reference standards in the prediction of pulmonary function. We conducted a study to determine whether the genetically determined percentage of African ancestry is associated with lung function and whether its use could improve predictions of lung function among persons who identified themselves as African American.MethodsWe assessed the ancestry of 777 participants self-identified as African American in the Coronary Artery Risk Development in Young Adults (CARDIA) study and evaluated the relation between pulmonary function and ancestry by means of linear regression. We performed similar analyses of data for two independent cohorts of subjects identifying themselves as African American: 813 participants in the Health, Aging, and Body Composition (HABC) study and 579 participants in the Cardiovascular Health Study (CHS). We compared the fit of two types of models to lung-function measurements: models based on the covariates used in standard prediction equations and models incorporating ancestry. We also evaluated the effect of the ancestry-based models on the classification of disease severity in two asthma-study populations.ResultsAfrican ancestry was inversely related to forced expiratory volume in 1 second (FEV(1)) and forced vital capacity in the CARDIA cohort. These relations were also seen in the HABC and CHS cohorts. In predicting lung function, the ancestry-based model fit the data better than standard models. Ancestry-based models resulted in the reclassification of asthma severity (based on the percentage of the predicted FEV(1)) in 4 to 5% of participants.ConclusionsCurrent predictive equations, which rely on self-identified race alone, may misestimate lung function among subjects who identify themselves as African American. Incorporating ancestry into normative equations may improve lung-function estimates and more accurately categorize disease severity. (Funded by the National Institutes of Health and others.)

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Genetic ancestry influences asthma susceptibility and lung function among Latinos.

Publications

Genetic ancestry influences asthma susceptibility and lung function among Latinos.

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