Ontology highlight
ABSTRACT:
SUBMITTER: Gignoux CR
PROVIDER: S-EPMC6927816 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Gignoux Christopher R CR Torgerson Dara G DG Pino-Yanes Maria M Uricchio Lawrence H LH Galanter Joshua J Roth Lindsey A LA Eng Celeste C Hu Donglei D Nguyen Elizabeth A EA Huntsman Scott S Mathias Rasika A RA Kumar Rajesh R Rodriguez-Santana Jose J Thakur Neeta N Oh Sam S SS McGarry Meghan M Moreno-Estrada Andres A Sandoval Karla K Winkler Cheryl A CA Seibold Max A MA Padhukasahasram Badri B Conti David V DV Farber Harold J HJ Avila Pedro P Brigino-Buenaventura Emerita E Lenoir Michael M Meade Kelley K Serebrisky Denise D Borrell Luisa N LN Rodriguez-Cintron William W Thyne Shannon S Joubert Bonnie R BR Romieu Isabelle I Levin Albert M AM Sienra-Monge Juan-Jose JJ Del Rio-Navarro Blanca Estela BE Gan Weiniu W Raby Benjamin A BA Weiss Scott T ST Bleecker Eugene E Meyers Deborah A DA Martinez Fernando J FJ Gauderman W James WJ Gilliland Frank F London Stephanie J SJ Bustamante Carlos D CD Nicolae Dan L DL Ober Carole C Sen Saunak S Barnes Kathleen K Williams L Keoki LK Hernandez Ryan D RD Burchard Esteban G EG
The Journal of allergy and clinical immunology 20180907 3
<h4>Background</h4>Asthma is a common but complex disease with racial/ethnic differences in prevalence, morbidity, and response to therapies.<h4>Objective</h4>We sought to perform an analysis of genetic ancestry to identify new loci that contribute to asthma susceptibility.<h4>Methods</h4>We leveraged the mixed ancestry of 3902 Latinos and performed an admixture mapping meta-analysis for asthma susceptibility. We replicated associations in an independent study of 3774 Latinos, performed targeted ...[more]