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Meta-analysis of tumor necrosis factor alpha -308 polymorphism and knee osteoarthritis risk.

ABSTRACT:

Background

Several case-control studies have been conducted to clarify the association between the tumor necrosis factor alpha (TNF-?) -G308A polymorphism and risk of osteoarthritis (OA); however, the results are inconsistent. This meta-analysis was performed to clarify this issue using all the available evidence.

Methods

Eligible articles were retrieved by searching PubMed, Web of science and Google scholar. The strength of the association between the TNF-? -G308A polymorphism and risk of OA was assessed by odds ratios (ORs) with the corresponding 95% confidence interval (CI) for each study.

Results

Seven studies were included in the meta-analysis, which included 983 OA cases and 1355 controls. The pooled analysis based on all included studies showed a significantly increased OA risk in the recessive genetic model analysis (OR?=?11.08, 95% CI?=?4.75-25.86, p?ConclusionOur results suggested that the TNF-? -G308A polymorphism were associated with an increased risk of OA.

SUBMITTER: Kou S

PROVIDER: S-EPMC4289255 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Publications

Meta-analysis of tumor necrosis factor alpha -308 polymorphism and knee osteoarthritis risk.

Kou Suotang S Wu Yaochi Y

BMC musculoskeletal disorders 20141115

<h4>Background</h4>Several case-control studies have been conducted to clarify the association between the tumor necrosis factor alpha (TNF-α) -G308A polymorphism and risk of osteoarthritis (OA); however, the results are inconsistent. This meta-analysis was performed to clarify this issue using all the available evidence.<h4>Methods</h4>Eligible articles were retrieved by searching PubMed, Web of science and Google scholar. The strength of the association between the TNF-α -G308A polymorphism an ...[more]

PMID: 25398219

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