Tumor necrosis factor-alpha-308 gene promoter polymorphism associates with survival of cancer patients: A meta-analysis.

ABSTRACT: BACKGROUND:Tumor necrosis factor-alpha (TNF-?) is involved in cancer pathogenesis, and TNF-?-308G>A, a single-nucleotide polymorphism, is associated with cancer prognosis; however, different studies have reported inconsistent results. This meta-analysis aimed to determine the correlation between TNF-?-308G>A polymorphism and the survival of cancer patients. METHODS:PubMed, Web of Science, Embase, Wanfang database, VIP database, and China National Knowledge Infrastructure database were used to obtain articles on association between TNF-?-308G>A polymorphism and cancer survival, published until April 2018. A meta-analysis was carried out using Stata 12.0 software to determine the pooled hazard ratio (HR) and 95% confidence intervals (95% CI). Furthermore, publication bias was assessed, and sensitivity analysis was performed to validate the analysis. RESULTS:In total, 13 retrospective cohort studies including 2559 cancer patients were reviewed to estimate the association between TNF-?-308G>A polymorphism and overall survival (OS) of cancer patients. The pooled results suggested that within TNF-?-308G>A polymorphism, genotypes GA+AA/GG (HR?=?1.39, 95% CI: 0.90-2.14, P?A polymorphism and OS among cancer patients (AA/GG, HR?=?2.16, 95% CI: 1.36-3.43, P?=?.281, I?=?21.5%). CONCLUSION:TNF-?-308G>A polymorphism affects the OS of cancer patients and is a potential therapeutic target for cancer.

SUBMITTER: Yi F 

PROVIDER: S-EPMC6250438 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature