Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC4289905 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Zhang Yue Y Zhou Chenguang C Kwak Kwang Joo KJ Wang Xinmei X Yung Bryant B Lee L James LJ Wang Yanming Y Wang Peng George PG Lee Robert J RJ
Pharmaceutical research 20120125 6
<h4>Purpose</h4>Delivery of siRNA into cells remains a critical challenge. Our lab has shown a novel polyamidoamine (PAMAM) dendrimer with modified pentaerythritol derivative core (PD dendrimer) to exhibit high plasmid DNA transfection efficiency and low cytotoxicity. Here, we evaluate PD dendrimer as a siRNA carrier.<h4>Methods</h4>Agarose gel electrophoresis and AFM were used to confirm formation of generation 5 (G5)-PD dendrimer/siRNA nanoparticles (NPs). G5 PD dendrimer/anti-luciferase siRNA ...[more]