Ontology highlight
ABSTRACT:
SUBMITTER: Bae Y
PROVIDER: S-EPMC6432117 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Bae Yoonhee Y Song Su Jeong SJ Mun Ji Young JY Ko Kyung Soo KS Han Jin J Choi Joon Sig JS
Polymers 20170529 6
The use of tumor-specific therapeutic agents is a promising option for efficient and safe nonviral gene transfer in gene therapy. In this study, we describe the efficacy of polyamidoamine (PAMAM)-based nonviral gene delivery carriers, namely, an ornithine conjugated PAMAM (PAMAM-O) dendrimer in delivering apoptin, a tumor-specific killer gene, into human hepatocellular carcinoma (HepG2 cells) and dermal fibroblasts. We analyzed the transfection efficiency by the luciferase assay and assessed cel ...[more]