HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck.
Ontology highlight
ABSTRACT:
SUBMITTER: Carlson JM
PROVIDER: S-EPMC4289910 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck.
Carlson Jonathan M JM Schaefer Malinda M Monaco Daniela C DC Batorsky Rebecca R Claiborne Daniel T DT Prince Jessica J Deymier Martin J MJ Ende Zachary S ZS Klatt Nichole R NR DeZiel Charles E CE Lin Tien-Ho TH Peng Jian J Seese Aaron M AM Shapiro Roger R Frater John J Ndung'u Thumbi T Tang Jianming J Goepfert Paul P Gilmour Jill J Price Matt A MA Kilembe William W Heckerman David D Goulder Philip J R PJ Allen Todd M TM Allen Susan S Hunter Eric E
Science (New York, N.Y.) 20140710 6193
Heterosexual transmission of HIV-1 typically results in one genetic variant establishing systemic infection. We compared, for 137 linked transmission pairs, the amino acid sequences encoded by non-envelope genes of viruses in both partners and demonstrate a selection bias for transmission of residues that are predicted to confer increased in vivo fitness on viruses in the newly infected, immunologically naïve recipient. Although tempered by transmission risk factors, such as donor viral load, ge ...[more]
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