Ontology highlight
ABSTRACT:
SUBMITTER: Deshpande AJ
PROVIDER: S-EPMC4291116 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Deshpande Aniruddha J AJ Deshpande Anagha A Sinha Amit U AU Chen Liying L Chang Jenny J Cihan Ali A Fazio Maurizio M Chen Chun-Wei CW Zhu Nan N Koche Richard R Dzhekieva Liuda L Ibáñez Gloria G Dias Stuart S Banka Deepti D Krivtsov Andrei A Luo Minkui M Roeder Robert G RG Bradner James E JE Bernt Kathrin M KM Bernt Kathrin M KM Armstrong Scott A SA
Cancer cell 20141120 6
Homeotic (HOX) genes are dysregulated in multiple malignancies, including several AML subtypes. We demonstrate that H3K79 dimethylation (H3K79me2) is converted to monomethylation (H3K79me1) at HOX loci as hematopoietic cells mature, thus coinciding with a decrease in HOX gene expression. We show that H3K79 methyltransferase activity as well as H3K79me1-to-H3K79me2 conversion is regulated by the DOT1L cofactor AF10. AF10 inactivation reverses leukemia-associated epigenetic profiles, precludes abn ...[more]