Ontology highlight
ABSTRACT:
SUBMITTER: Aoto K
PROVIDER: S-EPMC4291248 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Aoto Kazushi K Trainor Paul A PA
Human molecular genetics 20141006 3
Congenital brain and craniofacial defects often occur together as a consequence of their developmental dependency on common progenitor tissue interactions and signaling pathways during embryogenesis. A classic example of this is perturbation of midline embryo development, and disruption of Hedgehog (Hh) signaling in the pathogenesis of holoprosencephaly. However, our understanding of how Hh signaling governs cell and tissue survival remains incomplete. Patched1 (Ptch1) is a well-known receptor f ...[more]