Ontology highlight
ABSTRACT:
SUBMITTER: Murali A
PROVIDER: S-EPMC5520948 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Cell death & disease 20170629 6
Rho GTPases control fundamental cellular processes and Cdc42 is a well-studied member of the family that controls filopodia formation and cell migration. Although the regulation of Cdc42 activity by nucleotide binding is well documented, the mechanisms driving its proteostasis are not clear. Here, we demonstrate that the highly conserved, RING domain containing E3 ubiquitin ligase XIAP controls the protein stability of Cdc42. XIAP binds to Cdc42 and directly conjugates poly ubiquitin chains to t ...[more]