Ontology highlight
ABSTRACT:
SUBMITTER: Todt F
PROVIDER: S-EPMC4291481 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Todt Franziska F Cakir Zeynep Z Reichenbach Frank F Emschermann Frederic F Lauterwasser Joachim J Kaiser Andrea A Ichim Gabriel G Tait Stephen W G SW Frank Stephan S Langer Harald F HF Edlich Frank F
The EMBO journal 20141105 1
The Bcl-2 proteins Bax and Bak can permeabilize the outer mitochondrial membrane and commit cells to apoptosis. Pro-survival Bcl-2 proteins control Bax by constant retrotranslocation into the cytosol of healthy cells. The stabilization of cytosolic Bax raises the question whether the functionally redundant but largely mitochondrial Bak shares this level of regulation. Here we report that Bak is retrotranslocated from the mitochondria by pro-survival Bcl-2 proteins. Bak is present in the cytosol ...[more]