Ontology highlight
ABSTRACT:
SUBMITTER: McEnaney PJ
PROVIDER: S-EPMC4291750 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
McEnaney Patrick J PJ Fitzgerald Kelly J KJ Zhang Andrew X AX Douglass Eugene F EF Shan Weifang W Balog Aaron A Kolesnikova Mariya D MD Spiegel David A DA
Journal of the American Chemical Society 20141216 52
This article reports the design, synthesis, and evaluation of a novel class of molecules of intermediate size (approximately 7000 Da), which possess both the targeting and effector functions of antibodies. These compounds—called synthetic antibody mimics targeting prostate cancer (SyAM-Ps)—bind simultaneously to prostate-specific membrane antigen and Fc gamma receptor I, thus eliciting highly selective cancer cell phagocytosis. SyAMs have the potential to combine the advantages of both small-mol ...[more]