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Lymphocyte activation gene-3 (LAG-3, CD223) in plasmacytoid dendritic cells (pDCs): a molecular target for the restoration of active antitumor immunity.

ABSTRACT: We have recently reported that lymphocyte activation gene-3 (LAG-3,CD223) mediates the alternative, IFN?-deficient activation of plasmacytoid dendritic cells (pDCs) at tumor sites. Our findings define a novel tumor-driven strategy that promotes immunosuppression by pDCs, and we have provided more detailed information regarding the immunomodulatory role of of LAG-3. The translational relevance of our results for the treatment of tumors and autoimmune diseases is discussed herein.

SUBMITTER: Castelli C

PROVIDER: S-EPMC4292561 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Lymphocyte activation gene-3 (LAG-3, CD223) in plasmacytoid dendritic cells (pDCs): a molecular target for the restoration of active antitumor immunity.

Castelli Chiara C Triebel Frédéric F Rivoltini Licia L Camisaschi Chiara C

Oncoimmunology 20141101 11

We have recently reported that lymphocyte activation gene-3 (LAG-3,CD223) mediates the alternative, IFNα-deficient activation of plasmacytoid dendritic cells (pDCs) at tumor sites. Our findings define a novel tumor-driven strategy that promotes immunosuppression by pDCs, and we have provided more detailed information regarding the immunomodulatory role of of LAG-3. The translational relevance of our results for the treatment of tumors and autoimmune diseases is discussed herein. ...[more]

PMID: 25941596

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