Ontology highlight
ABSTRACT:
SUBMITTER: De Jager PL
PROVIDER: S-EPMC4292795 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Nature neuroscience 20140817 9
We used a collection of 708 prospectively collected autopsied brains to assess the methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that the level of methylation at 71 of the 415,848 interrogated CpGs was significantly associated with the burden of AD pathology, including CpGs in the ABCA7 and BIN1 regions, which harbor known AD susceptibility variants. We validated 11 of the differentially methylated regions in an independent set of 117 subjects. Furthermor ...[more]