Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.
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ABSTRACT:
SUBMITTER: De Jager PL
PROVIDER: S-EPMC4292795 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.
De Jager Philip L PL Srivastava Gyan G Lunnon Katie K Burgess Jeremy J Schalkwyk Leonard C LC Yu Lei L Eaton Matthew L ML Keenan Brendan T BT Ernst Jason J McCabe Cristin C Tang Anna A Raj Towfique T Replogle Joseph J Brodeur Wendy W Gabriel Stacey S Chai High S HS Younkin Curtis C Younkin Steven G SG Zou Fanggeng F Szyf Moshe M Epstein Charles B CB Schneider Julie A JA Bernstein Bradley E BE Meissner Alex A Ertekin-Taner Nilufer N Chibnik Lori B LB Kellis Manolis M Mill Jonathan J Bennett David A DA
Nature neuroscience 20140817 9
We used a collection of 708 prospectively collected autopsied brains to assess the methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that the level of methylation at 71 of the 415,848 interrogated CpGs was significantly associated with the burden of AD pathology, including CpGs in the ABCA7 and BIN1 regions, which harbor known AD susceptibility variants. We validated 11 of the differentially methylated regions in an independent set of 117 subjects. Furthermor ...[more]
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