Stem cells loaded with nanoparticles as a drug carrier for in vivo breast cancer therapy.
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ABSTRACT:
SUBMITTER: Cao B
PROVIDER: S-EPMC4292873 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
Stem cells loaded with nanoparticles as a drug carrier for in vivo breast cancer therapy.
Cao Binrui B Yang Mingying M Zhu Ye Y Qu Xuewei X Mao Chuanbin C
Advanced materials (Deerfield Beach, Fla.) 20140530 27
A novel anti-cancer drug carrier, mesenchymal stem cells (MSCs) encapsulating drug-loaded hollow silica nanoparticles, is used to carry a photosensitizer drug and deliver it to breast tumors, due to the natural high tumor affinity of the MSCs, and inhibit tumor growth by photo dynamic therapy. This new strategy for delivering a photo sensitizer to tumors by using tumor-affinitive MSCs addresses the challenge of the accumulation of photosensitizer drugs in tumors in photodynamic therapy. ...[more]
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