Dataset Information

Systemic inflammation in the extremely low gestational age newborn following maternal genitourinary infections.

ABSTRACT:

Problem

Gestational genitourinary infections are associated with lifelong disabilities, but it is unknown if neonatal inflammation is involved.

Method

Mothers of 914 infants born before 28th gestation week reported cervical/vaginal infection (CVI), and/or urine/bladder/kidney infection (UTI), or neither. Inflammation proteins measured in baby's blood on postnatal days 1, 7, and 14 were considered elevated if in the top quartile for gestational age. Logistic regression models adjusting for potential confounders assessed odds ratios.

Results

Compared to mothers with neither UTI/CVI, those with CVI were more likely to have infants with elevated CRP, SAA, MPO, IL-1β, IL-6, IL-6R, TNF-α, RANTES, ICAM-3, E-selectin, and VEGF-R2 on day 1; those with UTI were more likely to have infants with elevated MPO, IL-6R, TNF-R1, TNF-R2, and RANTES on day 7. Placental anaerobes and genital mycoplasma were more common in pregnancies with CVI.

Conclusion

Gestational UTI/CVI should be targeted for preventing systemic inflammation in the very preterm newborn.

SUBMITTER: Fichorova RN

PROVIDER: S-EPMC4293273 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Systemic inflammation in the extremely low gestational age newborn following maternal genitourinary infections.

Fichorova Raina N RN Beatty Noah N Sassi Rita R S RR Yamamoto Hidemi S HS Allred Elizabeth N EN Leviton Alan A

American journal of reproductive immunology (New York, N.Y. : 1989) 20140828 2

<h4>Problem</h4>Gestational genitourinary infections are associated with lifelong disabilities, but it is unknown if neonatal inflammation is involved.<h4>Method</h4>Mothers of 914 infants born before 28th gestation week reported cervical/vaginal infection (CVI), and/or urine/bladder/kidney infection (UTI), or neither. Inflammation proteins measured in baby's blood on postnatal days 1, 7, and 14 were considered elevated if in the top quartile for gestational age. Logistic regression models adjus ...[more]

PMID: 25164433

Similar Datasets

Project description:BackgroundChildren born extremely preterm (EP) are at increased risk of cognitive deficits that persist into adulthood. Few large cohort studies have examined differential impairment of cognitive function in EP-born adolescents in relation to early life risk factors, including maternal social disadvantage, gestational age at delivery, and neonatal morbidities prevalent among EP neonates.ObjectivesTo assess cognitive abilities in relation to early life risk factors in an EP-born cohort at 15 years of age.Methods681 of 1198 surviving participants (57%) enrolled from 2002 to 2004 in the Extremely Low Gestational Age Newborn Study returned at age 15 years for an assessment of cognitive abilities with the Wechsler Abbreviated Scale of Intelligence-II and the NIH Toolbox Cognition Battery (NTCB) verbal cognition and fluid processing composites, the latter of which measured executive functions and processing speed. Three cognitive outcomes, WASI-II IQ, NTCB verbal cognition, and NTCB fluid processing, were analyzed for associations with maternal social disadvantage and gestational age. Mediation of maternal social disadvantage by gestational age and mediation of gestational age by neonatal morbidities were also examined.ResultsTest scores were lower for NTCB fluid processing relative to IQ and NTCB verbal abilities. Social disadvantage and gestational age were associated with all three cognitive outcomes. Mediation analyses indicated partial mediation of gestational age associations with all three outcomes by neonatal morbidities but did not support mediation by gestational age of social risk associations with cognitive outcomes.ConclusionsGreater maternal social disadvantage and lower gestational age are associated with less favorable cognitive outcomes among EP-born adolescents at 15 years of age. Neonatal morbidities partially mediate associations between lower gestational age and cognitive outcomes. These findings highlight the need for improved medical and remedial interventions to mitigate risk of poor cognitive outcomes among EP-born adolescents.

Dataset Information

Systemic inflammation in the extremely low gestational age newborn following maternal genitourinary infections.

Problem

Method

Results

Conclusion

Publications

Systemic inflammation in the extremely low gestational age newborn following maternal genitourinary infections.

Similar Datasets

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