Combined use of Mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses is a powerful diagnostic tool of active tuberculosis.
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ABSTRACT:
SUBMITTER: Rozot V
PROVIDER: S-EPMC4293395 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Combined use of Mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses is a powerful diagnostic tool of active tuberculosis.
Rozot Virginie V Patrizia Amelio A Vigano Selena S Mazza-Stalder Jesica J Idrizi Elita E Day Cheryl L CL Perreau Matthieu M Lazor-Blanchet Catherine C Ohmiti Khalid K Goletti Delia D Bart Pierre-Alexandre PA Hanekom Willem W Scriba Thomas J TJ Nicod Laurent L Pantaleo Giuseppe G Harari Alexandre A
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20141031 3
Immune-based assays are promising tools to help to formulate diagnosis of active tuberculosis. A multiparameter flow cytometry assay assessing T-cell responses specific to Mycobacterium tuberculosis and the combination of both CD4 and CD8 T-cell responses accurately discriminated between active tuberculosis and latent infection. ...[more]
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