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Advances in the targeted therapy of liposarcoma.


ABSTRACT: Liposarcoma (LPS) is the most common type of soft-tissue sarcoma. Complete surgical resection is the only curative means for localized disease; however, both radiation and conventional cytotoxic chemotherapy remain controversial for metastatic or unresectable disease. An increasing number of trials with novel targeted therapy of LPS have provided encouraging data during recent years. This review will provide an overview of the advances in our understanding of LPS and summarize the results of recent trials with novel therapies targeting different genetic and molecular aberrations for different subtypes of LPS.

SUBMITTER: Guan Z 

PROVIDER: S-EPMC4293924 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Advances in the targeted therapy of liposarcoma.

Guan Zhonghai Z   Yu Xiongfei X   Wang Haohao H   Wang Haiyong H   Zhang Jing J   Li Guangliang G   Cao Jiang J   Teng Lisong L  

OncoTargets and therapy 20150105


Liposarcoma (LPS) is the most common type of soft-tissue sarcoma. Complete surgical resection is the only curative means for localized disease; however, both radiation and conventional cytotoxic chemotherapy remain controversial for metastatic or unresectable disease. An increasing number of trials with novel targeted therapy of LPS have provided encouraging data during recent years. This review will provide an overview of the advances in our understanding of LPS and summarize the results of rec  ...[more]

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