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Advances in targeted therapy for acute myeloid leukemia.


ABSTRACT: Acute myeloid leukemia (AML) is a clonal malignancy characterized by genetic heterogeneity due to recurrent gene mutations. Treatment with cytotoxic chemotherapy has been the standard of care for more than half of a century. Although much progress has been made toward improving treatment related mortality rate in the past few decades, long term overall survival has stagnated. Exciting developments of gene mutation-targeted therapeutic agents are now changing the landscape in AML treatment. New agents offer more clinical options for patients and also confer a more promising outcome. Since Midostaurin, a FLT3 inhibitor, was first approved by US FDA in 2017 as the first gene mutation-targeted therapeutic agent, an array of new gene mutation-targeted agents are now available for AML treatment. In this review, we will summarize the recent advances in gene mutation-targeted therapies for patients with AML.

SUBMITTER: Yu J 

PROVIDER: S-EPMC7238648 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Advances in targeted therapy for acute myeloid leukemia.

Yu Jifeng J   Jiang Peter Y Z PYZ   Sun Hao H   Zhang Xia X   Jiang Zhongxing Z   Li Yingmei Y   Song Yongping Y  

Biomarker research 20200520


Acute myeloid leukemia (AML) is a clonal malignancy characterized by genetic heterogeneity due to recurrent gene mutations. Treatment with cytotoxic chemotherapy has been the standard of care for more than half of a century. Although much progress has been made toward improving treatment related mortality rate in the past few decades, long term overall survival has stagnated. Exciting developments of gene mutation-targeted therapeutic agents are now changing the landscape in AML treatment. New a  ...[more]

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