Unknown

Dataset Information

0

Peritumoral Neuropilin-1 and VEGF receptor-2 expression increases time to recurrence in hepatocellular carcinoma patients undergoing curative hepatectomy.


ABSTRACT: To determined Neuropilin-1 (NRP-1) and vascular endothelial growth factor receptor 2 (VEGFR-2) expression in the tumoral and peritumoral tissues of 214 treatment-naïve HCC patients and its correlation with overall survival (OS) and time to recurrence (TTR).NRP-1 and VEGFR-2 expression were examined by tissue microarray and peritumoral hypoxia by pimonidazole staining and angiogenesis by microvessel density (MVD). OS and TTR were evaluated by Kaplan-Meier analysis and log-rank test.Peritumoral NRP-1 and VEGFR-2 expression were significantly higher than that of the tumoral tissue (p < 0.001 for both), and high peritumoral expression of both factors was negatively associated with tumor size (p < 0.001 for both). Patients with high peritumoral expression of both proteins had the longest median OS (>94.0 months) and TTR (>84.0 months). The multivariate Cox proportional hazards analysis revealed that patients with high peritumoral expression of both NRP-1 and VEGFR-2 were more than 4 times less likely to have recurrence (p = 0.004) and more than 10 times likely to survive (p < 0.001).Peritumoral NRP-1 and VEGFR-2 expression is associated with prolonged TTR and extended OS of HCC patients and both may be useful as predictors of surgical outcome of HCC patients and explored as potential therapeutic targets.

SUBMITTER: Zhuang PY 

PROVIDER: S-EPMC4294350 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Peritumoral Neuropilin-1 and VEGF receptor-2 expression increases time to recurrence in hepatocellular carcinoma patients undergoing curative hepatectomy.

Zhuang Peng-Yuan PY   Wang Jian-Dong JD   Tang Zhao-Hui ZH   Zhou Xue-Ping XP   Yang Yong Y   Quan Zhi-Wei ZW   Liu Ying-Bin YB   Shen Jun J  

Oncotarget 20141101 22


<h4>Purpose</h4>To determined Neuropilin-1 (NRP-1) and vascular endothelial growth factor receptor 2 (VEGFR-2) expression in the tumoral and peritumoral tissues of 214 treatment-naïve HCC patients and its correlation with overall survival (OS) and time to recurrence (TTR).<h4>Experimental design</h4>NRP-1 and VEGFR-2 expression were examined by tissue microarray and peritumoral hypoxia by pimonidazole staining and angiogenesis by microvessel density (MVD). OS and TTR were evaluated by Kaplan-Mei  ...[more]

Similar Datasets

| S-EPMC8217564 | biostudies-literature
| S-EPMC7082541 | biostudies-literature
| S-EPMC6391838 | biostudies-other
| S-EPMC6138409 | biostudies-literature
| S-EPMC3515597 | biostudies-literature
| S-EPMC4621918 | biostudies-literature
| S-EPMC4741890 | biostudies-other
| S-EPMC4428764 | biostudies-literature
| S-EPMC4720078 | biostudies-literature
| S-EPMC7977285 | biostudies-literature