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Simple parameters predicting extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma.


ABSTRACT: Extrahepatic recurrence (EHR) after curative hepatectomy for hepatocellular carcinoma (HCC) is associated with a poor prognosis. We investigated the features of EHR and identified its predictive factors. This retrospective study included 398 treatment-naive patients who underwent curative hepatectomy for HCC at two tertiary hospitals. Multivariate Cox-regression analysis was performed to identify the variables associated with EHR. EHR was diagnosed in 94 patients (23.6%) over a median follow-up period of 5.92 years, most commonly in the lungs (42.6%). The 5-/10-year cumulative rates of HCC recurrence and EHR were 63.0%/75.6% and 18.1%/35.0%, respectively. The median time to EHR was 2.06 years. Intrahepatic HCC recurrence was not observed in 38.3% of patients on EHR diagnosis. On multivariate analysis, pathologic modified Union for International Cancer Control stage (III, IVa), surgical margin involvement, tumor necrosis, sum of tumor size > 7 cm, and macrovascular invasion were predictive factors of EHR. Four risk levels and their respective EHR rates were defined as follows: very low risk, 1-/5-year, 3.1%/11.6%; low risk, 1-/5-year, 12.0%/27.7%; intermediate risk, 1-/5-year, 36.3%/60.9%; and high risk, 1-year, 100.0%. Our predictive model clarifies the clinical course of EHR and could improve the follow-up strategy to improve outcomes.

SUBMITTER: Yoon JH 

PROVIDER: S-EPMC8217564 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Simple parameters predicting extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma.

Yoon Jae Hyun JH   Lee Won Jae WJ   Kim Sun Min SM   Kim Kwang Tack KT   Cho Sung Bum SB   Kim Hee Joon HJ   Ko Yang Seok YS   Kook Hyun Yi HY   Jun Chung Hwan CH   Choi Sung Kyu SK   Kim Ban Seok BS   Cho Seo Yeon SY   You Hye-Su HS   Lee Yohan Y   Son Seyeong S  

Scientific reports 20210621 1


Extrahepatic recurrence (EHR) after curative hepatectomy for hepatocellular carcinoma (HCC) is associated with a poor prognosis. We investigated the features of EHR and identified its predictive factors. This retrospective study included 398 treatment-naive patients who underwent curative hepatectomy for HCC at two tertiary hospitals. Multivariate Cox-regression analysis was performed to identify the variables associated with EHR. EHR was diagnosed in 94 patients (23.6%) over a median follow-up  ...[more]

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