Ontology highlight
ABSTRACT:
SUBMITTER: Qi X
PROVIDER: S-EPMC4294380 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Qi Xiang X Ng Kevin Tak Pan KT Lian Qi Zhou QZ Liu Xiao Bing XB Li Chang Xian CX Geng Wei W Ling Chang Chun CC Ma Yuen Yuen YY Yeung Wai Ho WH Tu Wen Wei WW Fan Sheung Tat ST Lo Chung Mau CM Man Kwan K
Oncotarget 20141101 22
<h4>Aims</h4>We aimed to investigate the clinical significance of GPx3 in hepatocellular carcinoma (HCC) and to characterize its tumor suppressive role.<h4>Methods</h4>HCC patients (113) who underwent hepatectomy were recruited to examine the clinical relevance of GPx3. The tumor suppressive role of GPx3 was studied by administration of recombinant GPx3 (rGPx3) or over-expression of GPx3 in HCC cells in vitro and in vivo. The therapeutic value of GPx3 for HCC was further investigated using human ...[more]