Ontology highlight
ABSTRACT:
SUBMITTER: Nworu CU
PROVIDER: S-EPMC4294772 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Nworu Chinedu U CU Kraft Robert R Schnurr Daniel C DC Gregorio Carol C CC Krieg Paul A PA
Journal of cell science 20141127 2
Precise regulation of thin filament length is essential for optimal force generation during muscle contraction. The thin filament capping protein tropomodulin (Tmod) contributes to thin filament length uniformity by regulating elongation and depolymerization at thin filament ends. The leiomodins (Lmod1-3) are structurally related to Tmod1-4 and also localize to actin filament pointed ends, but in vitro biochemical studies indicate that Lmods act instead as robust nucleators. Here, we examined th ...[more]