Ontology highlight
ABSTRACT:
SUBMITTER: Tsukada T
PROVIDER: S-EPMC2931607 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Tsukada Takehiro T Pappas Christopher T CT Moroz Natalia N Antin Parker B PB Kostyukova Alla S AS Gregorio Carol C CC
Journal of cell science 20100824 Pt 18
Regulation of actin filament assembly is essential for efficient contractile activity in striated muscle. Leiomodin is an actin-binding protein and homolog of the pointed-end capping protein, tropomodulin. These proteins are structurally similar, sharing a common domain organization that includes two actin-binding sites. Leiomodin also contains a unique C-terminal extension that has a third actin-binding WH2 domain. Recently, the striated-muscle-specific isoform of leiomodin (Lmod2) was reported ...[more]