Ontology highlight
ABSTRACT:
SUBMITTER: Hammers CM
PROVIDER: S-EPMC4294994 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Hammers Christoph M CM Chen Jing J Lin Chenyan C Kacir Stephen S Siegel Don L DL Payne Aimee S AS Stanley John R JR
The Journal of investigative dermatology 20140714 3
Pemphigus vulgaris (PV) is a prototypic tissue-specific autoantibody-mediated disease, in which anti-desmoglein 3 (Dsg3) IgG autoantibodies cause life-threatening blistering. We characterized the autoimmune B-cell response over 14 patient years in two patients with active and relapsing disease, then in one of these patients after long-term remission induced by multiple courses of rituximab (anti-CD20 antibody). Characterization of the anti-Dsg3 IgG(+) repertoire by antibody phage display (APD) a ...[more]