Ontology highlight
ABSTRACT:
SUBMITTER: Wilk A
PROVIDER: S-EPMC4295376 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Wilk Anna A Wyczechowska Dorota D Zapata Adriana A Dean Matthew M Mullinax Jennifer J Marrero Luis L Parsons Christopher C Peruzzi Francesca F Culicchia Frank F Ochoa Augusto A Grabacka Maja M Reiss Krzysztof K
Molecular and cellular biology 20141020 1
Fenofibrate (FF) is a common lipid-lowering drug and a potent agonist of the peroxisome proliferator-activated receptor alpha (PPARα). FF and several other agonists of PPARα have interesting anticancer properties, and our recent studies demonstrate that FF is very effective against tumor cells of neuroectodermal origin. In spite of these promising anticancer effects, the molecular mechanism(s) of FF-induced tumor cell toxicity remains to be elucidated. Here we report a novel PPARα-independent me ...[more]