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A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.

ABSTRACT: Antigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only strain-specific protection has been reported by trials of such vaccines in nonhuman primates. We recently showed that P. falciparum reticulocyte binding protein homolog 5 (PfRH5), a merozoite adhesin required for erythrocyte invasion, is highly susceptible to vaccine-inducible strain-transcending parasite-neutralizing antibody. In vivo efficacy of PfRH5-based vaccines has not previously been evaluated. Here, we demonstrate that PfRH5-based vaccines can protect Aotus monkeys against a virulent vaccine-heterologous P. falciparum challenge and show that such protection can be achieved by a human-compatible vaccine formulation. Protection was associated with anti-PfRH5 antibody concentration and in vitro parasite-neutralizing activity, supporting the use of this in vitro assay to predict the in vivo efficacy of future vaccine candidates. These data suggest that PfRH5-based vaccines have potential to achieve strain-transcending efficacy in humans.

SUBMITTER: Douglas AD

PROVIDER: S-EPMC4297294 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.

Douglas Alexander D AD Baldeviano G Christian GC Lucas Carmen M CM Lugo-Roman Luis A LA Crosnier Cécile C Bartholdson S Josefin SJ Diouf Ababacar A Miura Kazutoyo K Lambert Lynn E LE Ventocilla Julio A JA Leiva Karina P KP Milne Kathryn H KH Illingworth Joseph J JJ Spencer Alexandra J AJ Hjerrild Kathryn A KA Alanine Daniel G W DG Turner Alison V AV Moorhead Jeromy T JT Edgel Kimberly A KA Wu Yimin Y Long Carole A CA Wright Gavin J GJ Lescano Andrés G AG Draper Simon J SJ

Cell host & microbe 20150101 1

Antigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only strain-specific protection has been reported by trials of such vaccines in nonhuman primates. We recently showed that P. falciparum reticulocyte binding protein homolog 5 (PfRH5), a merozoite adhesin required for erythrocyte invasion, is highly susceptible to vaccine-inducible strain-transcending parasite-neutraliz ...[more]

PMID: 25590760

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Dataset Information

A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.

Publications

A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.

Similar Datasets

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