Ontology highlight
ABSTRACT:
SUBMITTER: Peng X
PROVIDER: S-EPMC4297516 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20141217 3
A series of 2-methoxyphenyl piperazine analogues containing a triazole ring were synthesized and their in vitro binding affinities at human dopamine D2 and D3 receptors were evaluated. Compounds 5b, 5c, 5d, and 4g, demonstrate high affinity for dopamine D3 receptors and moderate selectivity for the dopamine D3 versus D2 receptor subtypes. To further examine their potential as therapeutic agents, their intrinsic efficacy at both D2 and D3 receptors was determined using a forskolin-dependent adeny ...[more]