Ontology highlight
ABSTRACT:
SUBMITTER: Platania CB
PROVIDER: S-EPMC3435408 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Platania Chiara Bianca Maria CB Salomone Salvatore S Leggio Gian Marco GM Drago Filippo F Bucolo Claudio C
PloS one 20120906 9
Dopamine (DA) receptors, a class of G-protein coupled receptors (GPCRs), have been targeted for drug development for the treatment of neurological, psychiatric and ocular disorders. The lack of structural information about GPCRs and their ligand complexes has prompted the development of homology models of these proteins aimed at structure-based drug design. Crystal structure of human dopamine D(3) (hD(3)) receptor has been recently solved. Based on the hD(3) receptor crystal structure we generat ...[more]