Ontology highlight
ABSTRACT:
SUBMITTER: Melichar HJ
PROVIDER: S-EPMC4297692 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20141217 3
Negative selection is one of the primary mechanisms that render T cells tolerant to self. Thymic dendritic cells play an important role in negative selection, in line with their ability to induce migratory arrest and sustained TCR signals. Thymocytes themselves display self-peptide/MHC class I complexes, and although there is evidence that they can support clonal deletion, it is not clear whether they do so directly via stable cell-cell contacts and sustained TCR signals. In this study, we show ...[more]