Ontology highlight
ABSTRACT:
SUBMITTER: Izumo M
PROVIDER: S-EPMC4298698 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Izumo Mariko M Pejchal Martina M Schook Andrew C AC Lange Ryan P RP Walisser Jacqueline A JA Sato Takashi R TR Wang Xiaozhong X Bradfield Christopher A CA Takahashi Joseph S JS
eLife 20141219
In order to assess the contribution of a central clock in the hypothalamic suprachiasmatic nucleus (SCN) to circadian behavior and the organization of peripheral clocks, we generated forebrain/SCN-specific Bmal1 knockout mice by using floxed Bmal1 and pan-neuronal Cre lines. The forebrain knockout mice showed >90% deletion of BMAL1 in the SCN and exhibited an immediate and complete loss of circadian behavior in constant conditions. Circadian rhythms in peripheral tissues persisted but became des ...[more]