Ontology highlight
ABSTRACT:
SUBMITTER: Welz PS
PROVIDER: S-EPMC8157517 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Welz Patrick-Simon PS Zinna Valentina M VM Symeonidi Aikaterini A Koronowski Kevin B KB Kinouchi Kenichiro K Smith Jacob G JG Guillén Inés Marín IM Castellanos Andrés A Furrow Stephen S Aragón Ferrán F Crainiciuc Georgiana G Prats Neus N Caballero Juan Martín JM Hidalgo Andrés A Sassone-Corsi Paolo P Benitah Salvador Aznar SA
Cell 20190501 6
Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond independently to environmental signals, or require interactions with each other to do so? We show that unexpectedly, light synchronizes the Bmal1-dependent circadian machinery in single ...[more]