Ontology highlight
ABSTRACT:
SUBMITTER: Evrony GD
PROVIDER: S-EPMC4299461 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Evrony Gilad D GD Lee Eunjung E Mehta Bhaven K BK Benjamini Yuval Y Johnson Robert M RM Cai Xuyu X Yang Lixing L Haseley Psalm P Lehmann Hillel S HS Park Peter J PJ Walsh Christopher A CA
Neuron 20150101 1
Somatic mutations occur during brain development and are increasingly implicated as a cause of neurogenetic disease. However, the patterns in which somatic mutations distribute in the human brain are unknown. We used high-coverage whole-genome sequencing of single neurons from a normal individual to identify spontaneous somatic mutations as clonal marks to track cell lineages in human brain. Somatic mutation analyses in >30 locations throughout the nervous system identified multiple lineages and ...[more]