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Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications.

ABSTRACT: Post-translational protein modifications are a dynamic method of regulating protein function in response to environmental signals. As with any cellular process, T cell receptor (TCR) complex-mediated signaling is highly regulated, since the strength and duration of TCR-generated signals governs T cell development and activation. While regulation of TCR complex-mediated signaling by phosphorylation has been well studied, regulation by ubiquitin and ubiquitin-like modifiers is still an emerging area of investigation. This review will examine how ubiquitin, E3 ubiquitin ligases, and other ubiquitin-like modifications such as SUMO and NEDD8 regulate TCR complex-mediated signaling.

SUBMITTER: Friend SF

PROVIDER: S-EPMC4299764 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications.

Friend Samantha F SF Deason-Towne Francina F Peterson Lisa K LK Berger Allison J AJ Dragone Leonard L LL

American journal of clinical and experimental immunology 20141205 3

Post-translational protein modifications are a dynamic method of regulating protein function in response to environmental signals. As with any cellular process, T cell receptor (TCR) complex-mediated signaling is highly regulated, since the strength and duration of TCR-generated signals governs T cell development and activation. While regulation of TCR complex-mediated signaling by phosphorylation has been well studied, regulation by ubiquitin and ubiquitin-like modifiers is still an emerging ar ...[more]

PMID: 25628960

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