Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors.
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ABSTRACT:
SUBMITTER: Berrios C
PROVIDER: S-EPMC4301141 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors.
Berrios Christian C Jung Joonil J Primi Blake B Wang Michael M Pedamallu Chandrasekhar C Duke Fujiko F Marcelus Christina C Cheng Jingwei J Garcea Robert L RL Meyerson Matthew M DeCaprio James A JA
Journal of virology 20141015 1
Malawi polyomavirus (MWPyV) is a recently identified human polyomavirus. Serology for MWPyV VP1 indicates that infection frequently occurs in childhood and reaches a prevalence of 75% in adults. The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53. However, the MWPyV LT was less stable than the simian virus 40 (SV40) LT and was unable to promote the growth of normal cells. This report confirms that MWPyV is a widespread h ...[more]
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