Functional comparison of induced pluripotent stem cell- and blood-derived GPIIbIIIa deficient platelets.
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ABSTRACT:
SUBMITTER: Orban M
PROVIDER: S-EPMC4301811 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Functional comparison of induced pluripotent stem cell- and blood-derived GPIIbIIIa deficient platelets.
Orban Mathias M Goedel Alexander A Haas Jessica J Sandrock-Lang Kirstin K Gärtner Florian F Jung Christian Billy CB Zieger Barbara B Parrotta Elvira E Kurnik Karin K Sinnecker Daniel D Wanner Gerhard G Laugwitz Karl-Ludwig KL Massberg Steffen S Moretti Alessandra A
PloS one 20150121 1
Human induced pluripotent stem cells (hiPSCs) represent a versatile tool to model genetic diseases and are a potential source for cell transfusion therapies. However, it remains elusive to which extent patient-specific hiPSC-derived cells functionally resemble their native counterparts. Here, we generated a hiPSC model of the primary platelet disease Glanzmann thrombasthenia (GT), characterized by dysfunction of the integrin receptor GPIIbIIIa, and compared side-by-side healthy and diseased hiPS ...[more]
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