Ontology highlight
ABSTRACT:
SUBMITTER: Borst S
PROVIDER: S-EPMC5675007 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Borst Sara S Sim Xiuli X Poncz Mortimer M French Deborah L DL Gadue Paul P
Arteriosclerosis, thrombosis, and vascular biology 20171005 11
Platelets, derived from megakaryocytes, are anucleate cytoplasmic discs that circulate in the blood stream and play major roles in hemostasis, inflammation, and vascular biology. Platelet transfusions are used in a variety of medical settings to prevent life-threatening thrombocytopenia because of cancer therapy, other causes of acquired or inherited thrombocytopenia, and trauma. Currently, platelets used for transfusion purposes are donor derived. However, there is a drive to generate nondonor ...[more]