Ontology highlight
ABSTRACT:
SUBMITTER: May-Simera HL
PROVIDER: S-EPMC4302998 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
May-Simera Helen L HL Petralia Ronald S RS Montcouquiol Mireille M Wang Ya-Xian YX Szarama Katherine B KB Liu Yun Y Lin Weichun W Deans Michael R MR Pazour Gregory J GJ Kelley Matthew W MW
Development (Cambridge, England) 20150201 3
Primary cilia have been implicated in the generation of planar cell polarity (PCP). However, variations in the severity of polarity defects in different cilia mutants, coupled with recent demonstrations of non-cilia-related actions of some cilia genes, make it difficult to determine the basis of these polarity defects. To address this issue, we evaluated PCP defects in cochlea from a selection of mice with mutations in cilia-related genes. Results indicated notable PCP defects, including mis-ori ...[more]