Ontology highlight
ABSTRACT:
SUBMITTER: Zhuang L
PROVIDER: S-EPMC6238533 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Zhuang Lizhe L Lawlor Kynan T KT Schlueter Holger H Pieterse Zalitha Z Yu Yu Y Kaur Pritinder P
Life science alliance 20180724 4
The cellular and molecular microenvironment of epithelial stem/progenitor cells is critical for their long-term self-renewal. We demonstrate that mesenchymal stem cell-like dermal microvascular pericytes are a critical element of the skin's microenvironment influencing human skin regeneration using organotypic models. Specifically, pericytes were capable of promoting homeostatic skin tissue renewal by conferring more planar cell divisions generating two basal cells within the proliferative compa ...[more]