Ontology highlight
ABSTRACT:
SUBMITTER: Hinz M
PROVIDER: S-EPMC4303448 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Hinz Michael M Scheidereit Claus C
EMBO reports 20131227 1
The IκB kinase (IKK) complex is the signal integration hub for NF-κB activation. Composed of two serine-threonine kinases (IKKα and IKKβ) and the regulatory subunit NEMO (also known as IKKγ), the IKK complex integrates signals from all NF-κB activating stimuli to catalyze the phosphorylation of various IκB and NF-κB proteins, as well as of other substrates. Since the discovery of the IKK complex components about 15 years ago, tremendous progress has been made in the understanding of the IKK arch ...[more]