Ontology highlight
ABSTRACT:
SUBMITTER: Potoyan DA
PROVIDER: S-EPMC4711861 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Potoyan Davit A DA Zheng Weihua W Komives Elizabeth A EA Wolynes Peter G PG
Proceedings of the National Academy of Sciences of the United States of America 20151223 1
Genetic switches based on the [Formula: see text] system are master regulators of an array of cellular responses. Recent kinetic experiments have shown that [Formula: see text] can actively remove NF-κB bound to its genetic sites via a process called "molecular stripping." This allows the [Formula: see text] switch to function under kinetic control rather than the thermodynamic control contemplated in the traditional models of gene switches. Using molecular dynamics simulations of coarse-grained ...[more]