Ontology highlight
ABSTRACT:
SUBMITTER: Peng T
PROVIDER: S-EPMC4303541 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20150112 2
Studying the functions of S-palmitoylated proteins in cells can be challenging due to the membrane targeting property and dynamic nature of protein S-palmitoylation. New strategies are therefore needed to specifically capture S-palmitoylated protein complexes in cellular membranes for dissecting their functions in vivo. Here we present a bifunctional fatty acid chemical reporter, x-alk-16, which contains an alkyne and a diazirine, for metabolic labeling of S-palmitoylated proteins and photo-cros ...[more]